Best Selling Medicine
Dr. Aditya Shah
Expert In Clinical Pharmacology And Drug SafetyView moreTadalafil is among the most sought-after ED medications among men. Not just men, Tadalafil is also prescribed to patients to BPH or Benign Prostatic Hyperplasia to counter the enlargement of prostate gland. Hence, women also consume Tadalafil when affected by BPH.
The common brand name popular for Tadalafil in medical circles is Cialis, however generic variations such as Vidalista 20 mg is also available. The main reason why Tadalafil is prescribed and sought over other ED pills is its longevity of 36 -hour working mechanism, also referred as the “weekend pill”.
Other ED drugs like Sildenafil work for one session for 3 to 4 hours then fade away. Whereas Tadalafil stays in the body for 36 hours and shows its effect multiple time after stimulation. But as its use all across the globe to treat ED is known, does it show any effect on fertility or sperm-health? Medical research since the advent of Tadalafil has shown positive results showcasing Tadalafil not to be the cause of fertility under any circumstance, rather it shows support to strengthen fertility.
The Mechanism Of Action: Tadalafil And The Reproductive System
To get in-depth understanding of Tadalafil’s effect on fertility we must first know the working mechanism of the drug. Tadalafil or any counter ED medicine, is a PDE5-inhibiting medicine. Its primary role is to suppress the working of PDE5 or phosphodiesterase type 5.
| Reproductive Function | Impact of Tadalafil |
|---|---|
| Penile Blood Flow | Increases blood circulation to erectile tissues |
| Erectile Function | Helps achieve and maintain erections |
| Sexual Performance | Supports improved sexual activity |
| Sperm Count | Generally no significant impact |
| Sperm Motility | May improve in some men according to studies |
| Sperm Quality | Usually remains unchanged |
By suppressing PDE5 tadalafil ensures sufficient production of cGMP or cyclic guanosine monophosphate. This keeps the pelvic muscles and blood vessels in penis smoothened and relaxed, which leads to heavy blood supply in penis after stimulation.
- Vascular Focus: The effect is seen specifically on the pelvic muscles including bladder and blood vessels of penis.
- Hormonal Preservation: Unlike other ED drugs Tadalafil does not messes with hormones such as testosterone.
- Presence in Semen: The presence of Tadalafil in blood is minute with concentration being so low that no damage to sperm’s health is ever caused. Few traces of Tadalafil may enter the testicles but cause no harm.
Direct Effects Of Tadalafil On Male Sperm Parameters
To check the effects of Tadalafil on male sperm’s health there are certain parameters to be monitored such as sperm count, motility, concentration etc. Certain trials have been conducted to analyze effect of regular consumption of Tadalafil on above metrics of male sperm health.
➯ Spermatogenesis and Sperm Count
The duration of full sperm formation cycle in males is around 74 days. Experiments were conducted with 10 – 20 mg of Tadalafil being fed for six months. It showed no harmful effects on sperm formation cycle and count.
- Concentration Stability: Population survey suggests the concentration of sperm in males remains the same.
- No Structural Disruption: The biological cycle of sperm from germ cells till their mature stage, spermatozoa, the production of cGMP has no effect on it.
➯ Sperm Motility and Vitality
Sperm motility refers to the sperm’s ability to swim so that it can reach ovaries and fertilize an egg to form zygote. The swimming capability of the sperm depends on factors such as lifestyle, metabolic reaction, medications etc.
- In Vivo Maintenance: Research shows that men fed with Tadalafil for consecutive 6 months had no change in motility.
- In Vitro Observations: In fact, instead of causing any harm, trial patients were observed with stable sperm motility on consuming Tadalafil regularly. The natural degradation of sperm’s swimming nature was delayed. But consumption of Tadalafil to improve sperm’s motility is still not scientifically considered.
➯ Sperm Morphology and DNA Integrity
Morphology means the shape and structure of the sperm such as its head, body and the tail. DNA integrity refers to the genetic information in the sperm. Research shows that consumption of Tadalafil results in no loss of shape, structure of genetic information and no mutation is triggered.
And the process of sperm entering the outer layer of female egg, acrosome reaction is also not affected in any way.
Note:
Tadalafil doesn’t directly boost sperm count or cure infertility, but it may help fertility efforts by improving erectile function and sexual performance.
Indirect Positive Impacts On Fertility
Though Tadalafil is primarily an ED drug to cause long lasting erection and has no direct effect on fertility. But in this process indirectly it has helped couples conceive offspring.
- Overcoming Performance Anxiety: One of the major causes of erectile dysfunction is anxiety to perform during the exact ovulation phase. Due to stress and lifestyle factors combined erection is hampered. Tadalafil ensures one gets a long-lasting erection ensuring high chances of conceiving.
- Frequency of Intercourse: To conceive, multiple sessions of intercourse is needed. Tadalafil is the best choice here as it gives 36-hour time window to allow as many sessions as possible. For other drugs, you have to take it each time before copulation.
- Anatomical Blood Flow: To cause erection blood supply in the pelvic region is ensured. This adequate blood supply not only causes erection but over the time maintains health of other sex glands, prostate and the concentration of seminal plasma remains stabilized as well.
Tadalafil’s Impact On Female Fertility
Usually, Tadalafil is thought to improve fertility in men only. But its consumption shows positive effect on female fertility as well:
- Endometrial Thickness: During its working process, nitric oxide is produced which ensures sufficient blood flow into uterus. This leads to thickening of endometrium ensuring healthy embryos.
- Pulmonary Hypertension Exceptions: In some cases, pregnant women are prescribed Tadalafil to treat PAH or Pulmonary Arterial Hypertension.
Frequently Asked Questions (FAQs)
Q. Can I Safely Take Tadalafil Or Vidalista 20mg If My Partner And I Are Trying To Get Pregnant?
Yes, backed with medical research Tadalafil has not negative effect on sperm health, motility, fertilization or any process.
Q. Does Tadalafil Increase Or Decrease A Man’s Testosterone Levels?
Tadalafil has no role to play to increase or decrease testosterone or any hormone. In fact, after regular consumption during the trial, men witnessed rise in testosterone levels due to high libido.
Q. Will Taking Tadalafil Treat Male Infertility?
Tadalafil is not a medication for infertility, its role is to provide erection, treat BPH and PAH.
Q. How Long Does Tadalafil Stay In The Body, And Does It Accumulate In Semen?
Tadalafil shows its effect for 36 hours. During this time, minute traces might enter testicles, but the concentration is so low it does not lead to any harm.
