Dr. Aditya Shah
Expert In Clinical Pharmacology And Drug SafetyView moreThere is a common misconception floating among ED patients that if they mix two ED drugs, the effect will be doubled with even long-lasting erection. Those who try this end up with suffering with side effects such as blood pressure dipping very low and even heart complications. Their existing Erectile Dysfunction gets worse with no extra positive effects of mixing ED medicines.
The Science Behind How These Medications Work
To get a better understand of why mixing two ED medicines like Viagra and Cialis don’t end up giving positive results, we must know the science behind it. Any ED medicine is classified as a PDE5 inhibiting drug.
- Vasodilation Effect: When sexually stimulated our body produces nitric oxide. This nitric oxide leads to formation of an enzyme cGMP or cyclic guanosine monophosphate. cGMP is responsible for smoothening of muscles in pelvic region. This leads to smooth blood flow in penis causing erection.
- Science of Dosing: In regular situations, PDE5 counters cGMP and erection is stopped after a certain duration. But when you take an ED medicine like Vidalista 20 or Cenforce 100 mg the PDE5 is suppressed, and cGMP keeps smoothening muscles in penis causing lasting erection. Taking 2 PDE5 suppressing drugs at the same time does not lead to better long-lasting erection rather it leads to overdose.
Comparison Of Cialis And Viagra:
| Factor | Cialis (Tadalafil) | Viagra (Sildenafil) | Taking Together |
|---|---|---|---|
| Main Use | Erectile Dysfunction | Erectile Dysfunction | Not usually recommended |
| Start Time | 30–60 min | 30–60 min | No significant added benefit |
| Duration | Up to 36 hrs | 4–6 hrs | Higher side-effect risk |
| Blood Pressure Effect | Lowers BP | Lowers BP | Increased BP drop risk |
| Doctor Approval Needed? | Yes | Yes | Strongly advised |
The Dangerous Risks Of Stacking ED Medications
Dose of 2 ED medicines excessively smoothen the muscles in pelvic region and widen blood vessels causing serious complications.
➯ Severe Hypotension
PDE5 inhibitors or any ED medicine when consumed widens blood vessels of penis, which lowers blood pressure. Taking 2 ED medicines, will widen the blood vessels and lead to a severe drop in blood pressure. Extreme low blood pressure might affect activity of vital organs. Common symptoms of severe hypotension include:
- Dizziness
- Hallucinations
- Fainting
- Cold Skin
- Fluctuating heartbeat
- Feeling too light on the head
➯ Priapism
Priapism is a very serious situation that can occur in case someone intakes 2 ED drugs. Here, the erection lasts for hours, causing intense pain. Taking 2 anti-ED medications stop PDE5 from working at all, hence blood cannot exit penis. This can lead to long-lasting damage such as permanent ED, tissue damage, and needs immediate medical help.
➯ Exacerbated Standard Side Effects
This is like a byproduct of consuming multiple medications at once. Consuming 2 medicines creates a situation where your bloodstream with filled with multiple traces of chemicals. This mixing of chemicals can trigger possible side effects:
- Acid Reflux
- Digestion Issues
- Muscle Aches
- Flushing in face
- Intense Migraine with temporary blindness
Understanding Generic Equivalents
The outcome of taking 2 branded counter ED medicines is the same in case of two generic anti-ED drugs like Vidalista 20 and Cenforce 100 mg.
Vidalista 20:
|
Medicines |
Tablet | Price | Price/Unit |
Buy Now |
| Vidalista 20 Mg | 600 Tablet/s | $400 | $0.67 |
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This drug contains the active ingredient Tadalafil. In Vidalista 20 it contains 20 mg Tadalafil. Cialis also contains Tadalafil as its active ingredient. Tadalafil remains active in the bloodstream for 36 hours. Hence, at any point within 36 hours if you are sexually stimulated you would get a hard erection.
For this long duration of its presence in the body, Tadalafil is also referred as “weekend pill.”
Cenforce 100mg:
|
Medicines |
Tablet | Price | Price/Unit | Buy Now |
| Cenforce 100 Mg | 600 Tablet/s | $363 | $0.61 |
🛒 Shop Now |
Here Sildenafil is the active ingredient. In Cenforce 100 mg, there is 100 mg of Sildenafil. In Viagra as well Sildenafil is the active ingredient. The work mechanism of Sildenafil is different compared to Tadalafil in case of Cialis.
Sildenafil provides immediate heavy blood flow in penis, causing hard erection. This usually lasts for 4 to 5 hours, then dies off. So, this works for instance when suddenly situation turns towards copulation and 30 minutes before you take Sildenafil. Whereas Tadalafil is for multiple instances within 3 days, more like planned.
Are They Ever Combined by Medical Professionals?
This is very rare, but in some situations, doctors may prescribe a combination in small scale. For example, a minor dose of Tadalafil may be prescribed for treating BPH or enlargement of prostate gland. And along with this Sildenafil may also be given in minor quantities for ED treatment.
But chances of this combination to be prescribed is very low. And doctors will do this only after full cardiac health checkup. On your own, you should never try this, it can cause fatal situations even life-threatening ones.
Taking Cialis and Viagra together without medical supervision may result in dangerous drops in blood pressure and severe side effects.
Emergency Protocol For Accidental Ingestion
In case you have accidentally consumed Cialis and Viagra, you must act without panicking but take quick steps.
Monitor Your Vitals:
Check your blood pressure and pulse rate. You may fill extremely dizzy, hence, to avoid falling lie down or sit with a support. Avoid driving, even going for medical help take someone with you.
Know When To Seek Immediate Emergency Care:
In case of:
- Chest pain
- Breathlessness
- Feeling dizzy
- Sudden blindness in one or both eyes
- Temporary hearing inability
- Prolonged erection may lead to priapism where erection lasts for more than 4 hours.
Frequently Asked Questions (FAQs)
Q. What Should I Do If My Current ED Medication Is Not Working?
Do not take any step on your own. Tell the doctor about inefficiency of your current medication, you might be prescribed a different drug or combination of drugs. Or they can ask for tests to check for any other underlying reason for ED.
Q. How Long Must I Wait When Switching From Cialis To Viagra?
As tadalafil is the active ingredient in Vidalista 20 and Cialis, it stays in bloodstream for 36 hours. So, wait for this drug to exit the bloodstream then take first dose of Viagra. So, you have to wait for 36 – 48 hours after taking Cialis to shift to Viagra.
Q. Can I Take These Medications If I Am On Blood Pressure Or Heart Medicine?
No, this shall never be even tried, this could even cause death. Heart or blood pressure medicines are form of nitrates and PDE5 suppressing drugs (ED drugs) react aggressively with nitrates, causing multitude of side effects. To avoid this, while checkup for ED tell your doctor about your other disorders and any ongoing medications.

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