Best Selling Medicine
Dr. Aditya Shah
Expert In Clinical Pharmacology And Drug SafetyView moreSildenafil is one of the major components used in most of the ED (erectile dysfunction) pills. It has the ability to give males a hard erection, although they are suffering from such disorders where they cannot get an erection.
Brand Names:
- Liqrev®
- Revatio®
- Viagra®
Cenforce 100, the generic name of sildenafil, works with absolute critics, where it deals with the enzymes that narrow down the pelvic blood vessels and also works on the hypertension to increase blood flow.
However, sildenafil interacts with some other drugs, foods, and existing disorders. Hence, while you are taking it, you must make yourself secure from all these. Here, we will give you a perfect overview of the interactions of Sildenafil, where you must stay careful. But before that, make the working mechanism of sildenafil clear to yourself, as the working mechanism will help you understand the interactions well enough.
- Drug Classes: phosphodiesterase-5 (PDE5) inhibitor
- Availability: prescription only, generic available
- Medication Category: PDE-5 inhibitor
- Prescription Status: Prescription-only medicine
- Forms of Use: Taken orally as a tablet or liquid
- How Is It Used?: Taken by mouth as a tablet or liquid
Working Mechanism Of Sildenafil
Sildenafil works on your pelvic blood vessels and blood pressure to normalize your erection. To ensure that, it needs to work on the cGMP level of your blood that ensures healthy and softer blood vessels, which can be easily taken away.
Now, your liver secretes PDE5, a type of enzyme that blocks cGMP. When it blocks the cGMP, your blood vessels become tougher, and they do not remain in a relaxed condition to be flown down to the penis tip. Naturally, you won’t get the erection that you need for penetration, which eventually puts you away from sexual intimacy.
| Step | What Happens | Result |
|---|---|---|
| 1 | Sexual stimulation occurs | Nerve signals activate the erection process |
| 2 | Nitric oxide is released | Triggers chemical response |
| 3 | cGMP levels increase | Smooth muscles relax |
| 4 | Blood vessels widen | More blood flows to the penis |
| 5 | Sildenafil blocks PDE-5 | cGMP breakdown is prevented |
| 6 | Sustained blood flow | Firm, longer-lasting erection |
Cenforce 150mg, the generic version of sildenafil containing 150mg of Sildenafil, stops the flow of PDE5 and therefore normalizes cGMP, ensuring smooth blood flow. The same continues for 4 hours, and thus, your erection is maintained for the full 4 hours.
There is another area where if you have any anomaly, you will not get an erection. It is the blood flow to the penile region. The same depends on the blood pressure, and if it is high, the blood reaching the pelvic will be tougher. Cenforce 200 ensures that too, and for that, it reduces your blood pressure and keeps it such for 4 hours to ensure a 4-hour erection for you.
Your Sildenafil Product Is Here For Reliable Treatment:
Interactions Of Sildenafil:
The mechanism is clear to you by now. Hence, the thing that you need to go through is the interaction, which was your original query. We will now cover all the types of interactions you can face with Sildenafil.
➯ Drug Interactions:
Nitrates: This is the major interacting drug with sildenafil and all the generic versions of the same, like Fildena 100. It can be some variants of isosorbide or some poppers. Whatever be the nitrate form, it reacts with Sildenafil the most and ensures the most critical side effects. Among the side effects, you can face with the nitrates, there are chest pain, extreme dizziness or fainting, and even a heart attack.
Alpha-blockers: Usually used to treat enlarged prostates, they also reduce the blood pressure of a patient. Hence, while the same is taken with Cenforce 100, the same can cause a heavy or fatal fall in blood pressure, which can even lead to fainting.
Blood pressure medications: If you are taking some blood pressure pills, if it is for lowering your blood pressure, it will cause overdosing of sildenafil and cause an extreme fall in BP, or if it is for dealing with low BP, then that will reduce the working of Sildenafil and will affect your male erection.
Blood thinners: The major role played by the blood thinners is to reduce your BP, the same as sildenafil. Therefore, the same when taken with Cenforce 150mg will be deemed by your body as an overdose of Sildenafil, and hence, BP can reach a fatal low level, causing fainting.
Antibiotics: Erythromycin-like antibiotics and ritonavir-type antifungal medicines, when reacts with sildenafil shows many side effects, as according to the lab reports.
Riociguat: This is another medication that works on the blood pressure and hence, when working with sildenafil, will overdose it to cause a fatal fall in BP, which can even faint you.
➯ Food Interactions:
Just stay out of the three types of foods and beverages as they interact with sildenafil:
Alcohol: You will face extreme dizziness when you take Sildenafil with alcohol, where the end-result can be as fatal as fainting or a heart attack.
Grapefruits: Grapefruits can be venomous when taken with sildenafil. It can even make a patient fall with chronic chest pain, and if not done, extreme dizziness is absolutely common.
Bulky meals: Taking junk food is not good at all when you have ED. However, when you take sildenafil pills like Fildena 100, and have a bulky meal before taking the pill, the absorption of sildenafil in your blood is delayed, and you face no erection, low erection, or late erection.
➯ Interactions With Existing Medical Conditions:
Liver medicines: Since sildenafil works on the liver to interrupt the action of the PDE5 enzyme, when you take Sildenafil with some liver medications, you take usually, can face liver issues.
You can take Cenforce 200 with some liver medications, but there may be a need for dosage adjustment.
Heart medicines: Heart medication, heart surgery in the last year, can be dangerous with Sildenafil. They can even be life-threatening for a patient.
Inform the same to your doctor. He will make the right decision for you.
ADHD medicines: Sildenafil, when it reacts with ADHD pills, can cause critical issues to your mental health.
It can even make you wild in bed, and you can behave weirdly with your partner.
FAQs
Q. What Is The Onset Of Action For Sildenafil?
Sildenafil takes 30-60 minutes to dissolve in your blood and start giving you an erection.
Q. How Long Does Sildenafil Act On My Erection?
Sildenafil works for nearly 4 hours on your erection. If you exceed that time and feel pain, inform your doctor.
Q. Can Sildenafil Cause Insomnia?
No, there is no such report available from the labs, clinics, and not even from the patients.
Q. Can My Partner Take Sildenafil?
No, sildenafil is only meant for males. Females and children must be kept away from it.
Q. Is Sildenafil Legal?
Yes, the FDA has approved it for use in ED treatment. Different other regulatory boards around the globe also approved the same.
Q. What Is The Best Place To Buy Sildenafil?
You can buy it from Powpills, the most reliable store of generic medicines. They stock the medicines directly from the FDA-approved manufacturers. Hence, you can get the medicines at a cheaper rate from there.