Sildenafil Citrate: Clinical Trials and Case Study

Don’t you get penis-hard erections and wonder what this issue all about is? Well, in case symptoms such as lack of hard erections or inability to hold hard erections longer occur often, it is time that you go to a doctor because the issues that are coming right now could be the first signs of erectile dysfunction.

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Even though this issue may at first seem like a big obstacle in your sex life, in this article, we are going to know about Sildenafil a form of generic substance that can give rise to a hard erection. Our main aim will be to find out more about the studies and reports of this generic medicinal item in medicines in more detail.

What Is Sildenafil Citrate?

Sildenafil Citrate in simple words is a form of generic substance present in different pills. In case you are taking, a pill with this composition inside, it helps you to get a strong and hard erection.

Sildenafil is of a class, the first of its kind generic PDE-5 hormone inhibitor that helps you to get a strong and hard erection for long hours. Even if you have an ED disorder having a pill with Sildenafil inside makes all ED issues go away as you can get strong and hard erections once again.

Medical Conditions Treated With Sildenafil

Sildenafil, with its popular brand names like Viagra in the US, and other generic brands like Cenforce is a leading medicine in the treatment of ED or erectile dysfunction. Being an effective PDE-5 hormone inhibitor, it is a cost-effective and simple way to manage signs of ED and enjoy having sex with your partner.

Clinical Update On Sildenafil Citrate

Sildenafil Citrate: clinical trials and case studies so far show a very positive outcome about the penis sexual issue ED. Sildenafil generic Cenforce has so far passed a lot of case studies and human trials that indicate the medicine to be highly effective in terms of curing ED problems.

Features Sildenafil
Dosage 100 Mg , 150 Mg , 200 Mg , 120 Mg
Effectiveness 82% Effective
Strength Stronger
Side Effects More Likely
How To Take Take 1 Hour before Sex On An Empty Stomach
Molecular Formula C28H38N6O11S

This medicine works to help you get a strong erection. In many studies, it has been found that the pill works across any age and with all severities of ED and equally proves its worth to help you get a strong and hard erection.

What Is Sildenafil Citrate Used For?

As we told you above, a generic element such as Sildenafil helps you to get a strong and hard erection. It is a sort of generic PDE-5 Inhibitors, which helps block the action of the hormone that is responsible for controlling the flow of blood in the arteries.

As an effect of this pill, as you can understand, it helps the blood flow through the arteries to increase allowing the penis areas to get highly sensitive because of which you can get a strong and hard erection.

A Comparative Study Of PDE5 Inhibitors Efficacy

After studying the effects of different PDE-5 hormone inhibitors like Sildenafil, and Tadalafil, scientists plotted the actions on a bar graph. The aim was to find out the effectiveness of each generic substance that cures ED and do a comparative analysis of them.

A-Comparative-Study

Based on the graphs and plots it has been found that Sildenafil Citrate has a strong efficacy rate as it has worked successfully in close to 80% men.

This goes on to show just how effective generic Cenforce or Viagra as a brand of Sildenafil is to cure ED.

Scientists also did a study and charted out the effects of Sildenafil along with other generic PDE-5 Inhibitors hormone inhibitors in different age groups. As per this study, it has been found to work with the same efficacy at any adult age in ED males between 18 to 64 years.

How Does Sildenafil Work?

Duration Of Efficacy

 

So far, we have come to know that Sildenafil will get to work by taking out the action of the PDE-5 hormones.

 

However, how does this get you to a hard erection?

 

Let us find out about this so, that after the PDE-5 hormone actions are not present it will increase the action of the cGMP enzyme in your body that helps nitric oxide to get active.

 

This allows for vasodilatation, meaning that the blood flow gets smoother in the penis tissues when you masturbate the penis, and this leads to a strong erection.

 

How Is Sildenafil Supplied (Dosage Forms)?

Sildenafil comes in many different doses, from the mild ones to the higher variants. Let us take you through some of the variants-

Strength          25 Mg 50 Mg 100 Mg
Dosage type    Minimum Standard Maximum
Quantity          One tablet a day One tablet a day One tablet a day

Most of the time the variants of Sildenafil come in the form of orally swallowing doses. However, it is important that you get the dose amount and the timing right to be able to get a strong erection.

How Should I Take Sildenafil?

Most often, you have to take Sildenafil brands like Cenforce 150 by way of mouth and that is to swallow the medicine. However, a lot of other Sildenafil Citrate: Clinical trials and case studies have shown newer methods can be used as well.

This is why you may see many new brands coming up in different forms like chewable or dispersible tablets and so on.

The Duration Of Efficacy For ED Medications

The-Duration-Of-Efficacy-For-ED

Scientists did many trials on men with ED with the use of different ED medicines each

one with a different composition in it. The aim here was to find out the duration or effectiveness of the medicine inside a patient.

Based on this it was found that Sildenafil actions were active in 90% of men for about 5 to 6 hours. However, it was found that after 4 hours of duration, the efficacy of Sildenafil dropped below 80%.

When compared with Tadalafil especially, generic Cialis seemed to be much more long-lasting. Graph plots show that Tadalafil even after 4 hours had an efficacy close to 90%.

A research trial was also done to find out how long these ED generic substances like Sildenafil, Tadalafil, or Vardenafil would take to get into action.

It was found that Cenforce took close to 30-60 minutes to be activated depending on the amount of dose being used. Tadalafil took much longer time generally varying at 45-60 minutes depending on dose. Vardenafil activation time looks almost the same as that of Sildenafil, which too around 25 minutes to an hour for activation.

Sildenafil Side Effects

Some of the most common issues with Sildenafil are-

  • Headache
  • Dizziness
  • Nausea
  • Palpitations
  • Flushing
  • Mouth dryness
  • Vomiting
  • Diarrhoea

Serious Side Effects

There are a few serious side effects that are possible with this pill too; however, these would be the few rare ones. Let us find out what these severe side effects can be like-

Serious Side Effects

 

What Special Precautions Should I Follow?

There are a few caution tips that patients need to follow when they are taking Sildenafil. Here is what you have to follow-

  • Avoid taking excess doses or too often
  • Avoid the use of alcohol and narcotic drugs
  • Avoid dangerous activities like car driving if any side effects occur
  • Get to the doctors for the right advice when having side effects

Important Warnings

There are a few warnings that have come out in Sildenafil Citrate: Clinical Trials and Case Study. In addition, this is related to the use of other medicines or existing health issues of the patient.

Here is a list of medicines that may be risky to use-

  • Pills with alpha and beta blockers in it
  • Pills that help increase blood flow or influence BP levels
  • Pills that come with nitrates in them

In addition, the sort of disorders with which it may not be safe to take Cenforce 200 mg are-

  • High BP
  • Having any form of cardiac disorder
  • A liver disorder especially fatty liver, jaundice
  • A severe kidney issue that needs a transplant or has a severe infection

Globally Customer Satisfaction Ratings For Sildenafil

To find out the global usage and satisfaction levels scientists did a study using plots to find out the use and satisfaction rates in different countries.

As per the plotted bar chart of consumers, it was found that the use of Sildenafil was especially high in countries like the USA and India. However, countries like Japan Germany, and even Brazil had a fair share of patients using different Sildenafil brands.

Globally-Customer

When comparing satisfaction and reviews of customers in different countries it was found that patients had given around 8/10 rating on efficacy, with 7/10 for side effect chances. People seemed to be highly satisfied with the low cost of Sildenafil brands with an average rating of more than 9/10 from customers.

Summary And Recommendations

So, as you can see, different Sildenafil citrate: trials and case studies have been done so far with good effects. It seems that the medicine can give a quick remedy for ED problems.

FAQs

Q. Where To Buy Sildenafil?

Sildenafil and its common brands can be accessed anywhere whether it is the local Pharma shops or the online pharmacies.

Q. When Not To Take Sildenafil Pills?

You cannot take Sildenafil pills if-

  • An intense side effect occurs
  • If you use any interacting medicine or have health issues
  • If you have an allergy to this generic substance

Q. Is Sildenafil For Women?

New case studies have shown that Sildenafil can be equally good for women too where it can help them to get a better orgasm.

Sources:

https://pmc.ncbi.nlm.nih.gov/articles/PMC1874305/

https://www.sciencedirect.com/science/article/pii/S0149291898801033